During Dominic Toretto's transfer to Lompoc Prison via a prison transport bus, his sister Mia Toretto and friend Brian O’Conner launch a daring rescue operation, successfully freeing him. As authorities begin a widespread manhunt, the trio flees to Rio de Janeiro for safety. While waiting for Dominic’s arrival, Brian and Mia join their old friend Vince and a team to execute a heist involving the theft of three cars from a moving train.

Brian and Mia quickly realize that the train also carries DEA agents, as the cars in question are seized assets. When Dominic arrives with his crew, he notices that their leader, Zizi, seems exclusively interested in stealing a specific car: a Ford GT40. Sensing trouble, Dominic instructs Mia to take the vehicle herself and flee. Meanwhile, he and Brian engage in a fight with Zizi and his men, during which Zizi kills one of the DEA agents. 

Eventually, Dominic and Brian are captured and brought to Hernan Reyes, a powerful drug lord who owns the cars and serves as Zizi’s boss. Reyes orders them to reveal the car’s location during an interrogation, but the pair manages to escape and make it back to their safe house.