After successfully pulling off a heist in Brazil, Dominic Toretto and his crew go into hiding across the globe, each settling into a quieter life. Dominic is living with Elena Neves, while his sister Mia resides with Brian O'Conner and their son, Jack. Gisele Yashar and Han Lue are together, and Roman Pearce and Tej Parker enjoy lives of luxury. Meanwhile, DSS agents Luke Hobbs and Riley Hicks are investigating a mercenary group led by former British SAS operative Owen Shaw, which has recently destroyed a Russian military convoy.

Hobbs tracks down Dominic and persuades him to help capture Owen by revealing a photo of Letty Ortiz, Dominic's girlfriend, who was presumed dead. Letty, however, is alive and now working with Owen's team. Initially, Dominic wants to handle the mission alone, but Hobbs argues that the strength of his "family" is essential. When Dominic’s team assembles at their headquarters, Hobbs informs them that Owen is stealing components to build a weapon known as "Nightshade," an electromagnetic pulse device, intended for sale to the highest bidder. In exchange for their assistance, the team is promised full pardons for their previous crimes.