On January 24, 2020, Columbia Pictures revealed plans for a reboot of the 1997 cult classic *Anaconda*, with Evan Daugherty set to pen the screenplay. In March 2023, Tom Gormican was announced as the film’s director. By August 2024, Jack Black and Paul Rudd were cast in the leading roles, with Gormican officially confirmed to direct from a screenplay he co-wrote with Kevin Etten. The following month, Daniela Melchior joined the cast. In January 2025, additional cast members Thandiwe Newton, Steve Zahn, Selton Mello, and Ione Skye were brought on board. Principal photography for the project commenced that same month in Australia.